Previous studies have demonstrated that functional connectivity (FC) of different brain regions in resting state function MRI were abnormal in patients suffering from mild cognitive impairment (MCI) and Alzheimer's disease (AD) when comparing to healthy controls (HC) using seed based, independent component analysis (ICA) or small world network techniques A new techniqueUp and downregulation of neuronal activity alter myelin and white matter in animal models SampaioBaptista et al demonstrate using fMRI neurofeedback that bidirectional regulation of sensorimotor activity results in bidirectional changes in white matter in adult humans fMRI neurofeedback can be used to directionally modulate brain structureThe map represents a restingstate functional connectivity analysis performed on 1,000 human subjects, with the seed placed at the currently selected location Thus, it displays brain regions that are coactivated across the restingstate fMRI time series with the seed
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